Although the exact mechanism of action of Bleomycin is unknown, available evidence indicates that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis.

Bleomycin is known to cause single, and to a lesser extent, double-stranded breaks in DNA.  In in vitro and in vivo experiments, Bleomycin has been shown to cause cell cycle arrest in G2 and in mitosis.

When administered into the pleural cavity in the treatment of malignant pleural effusion, Bleomycin acts as a sclerosing agent.

INDICATION

Bleomycin Sulfate Injection should be considered a Palliative Treatment. It has been shown to be useful in the management of the following neoplasms either as a single agent or in proven combinations with other approved

Bleomycin is used to treat cancer. It works by slowing or stopping the growth of cancer cells.

This medication may also be used to control the build-up of fluid around the lungs (pleural effusion) caused by tumors that have spread to the lungs. For this condition, bleomycin is placed in the space around the lungs through a chest tube.
chemotherapeutic agents: Squamous Cell Carcinoma in Head and neck including mouth, tongue, tonsil, Nasopharynx, Oropharynx, Sinus, palate, Lip, Buccal Mucosa, Gingivae , Epiglottis, skin, Larynx, Penis, Cervix, and Vulva. Lymphomas, Testicular Carcinoma, Malignant Pleural Effusion.